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Tuesday, April 21, 2020 | History

2 edition of Response of liver proteins to dietary and physiological stress in the rat. found in the catalog.

Response of liver proteins to dietary and physiological stress in the rat.

Margaret Carol Cheney

Response of liver proteins to dietary and physiological stress in the rat.

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  • 25 Currently reading

Published in [Toronto] .
Written in English

    Subjects:
  • Protein research

  • Edition Notes

    ContributionsToronto, University.
    The Physical Object
    Pagination[14], 230 leaves.
    Number of Pages230
    ID Numbers
    Open LibraryOL19044084M

    the consequences of high-protein feeding on the regulation and pathways of glucose disposal through glycogen metabolism and gluconeogenesis remain unclear. High-protein feeding induced both insulin and glucagon secretion in the fed state, associated with the repletion of glycogen stores (3, 45, 52), whereas excess dietary amino acids are metabolized within tissues and the Cited by:   ABSTRACT. To gain a comprehensive understanding of the molecular mechanisms underlying the effects of dietary protein on alternations in physiologic and pathologic status, the GeneChip microarray system was used to investigate the consequences of two different states of protein malnutrition on gene expression in rat by:   It was found that these liver enzymes could be divided roughly into 4 types with respect to the response curves of these activities obtained by plotting against the dietary protein level. 3. The enzymes of the first type decreased in rats fed protein-free or low protein diets, but did not change greatly after reaching the maximal value with Cited by: The unfolded protein response transducer IRE1a prevents ER stress-induced hepatic steatosis Kezhong Zhang1,2,3,*, Shiyu Wang1, Jyoti Malhotra1, Justin R Hassler1, Sung Hoon Back4, Guohui Wang2, Lin Chang5, Wenbo Xu2, Hongzhi Miao6, Roberta Leonardi7, Y Eugene Chen5, Suzanne Jackowski7 and Randal J Kaufman1,8,* 1Department of Biological Chemistry, .


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Response of liver proteins to dietary and physiological stress in the rat. by Margaret Carol Cheney Download PDF EPUB FB2

Abstract. The influence of prolonged protein deprivation followed by protein repletion in the adult male rat upon liver neutral glycerides and cholesterol was studied. Neutral glyceride and cholesterol concentrations increased for 8 weeks.

Thereafter neutral glycerides decreased to normal and cholesterol to below normal after 14 weeks of Cited by: This immunohistochemical study was performed to analyze the distribution of three stress proteins (HSP25, HSP72, GRP75) in rat kidney and liver orally exposed to.

Further dynamic proteomic research used fluorescence difference gel electrophoresis, found 42 changed proteins in the liver of chronic restraint stress rats, and validated 3 proteins to suggest how functional proteins act on metabolites to produce energy and process materials in rat liver as it responds to restraint stress.

More and more evidences have shown that stress may have an Cited by: 8. shangxin Song Distinct physiological, plasma amino acid and liver transcriptome responses to purified dietary beef, chicken, fish, and pork proteins in.

Synthesis of a kDa protein present in control liver was inhibited 2 hr after exposure with synthesis restored at hr. Dose-related increases in synthesis of the three stress proteins were observed 4 hr after iv injection of and mg Cd/kg, with concomitant inhibition of synthesis of the kDa by: Liver glucocorticoid receptor and heat shock protein 70 levels in rats exposed to different stress models Dragana Filipović, Ljubica Gavrilović, Sladjana Dronjak, Miroslav Demajo, Marija B.

Radojčić “VINČA“ Institute of Nuclear Sciences,Laboratory of Molecular Biology and Endocrinology, Belgrade, Serbia. Increased Response of Liver Response of liver proteins to dietary and physiological stress in the rat. book Δ6Desaturase Activity to Dietary Methionine in Rats Article in Bioscience Biotechnology and Biochemistry 67(4) May with 11 Reads.

Blood levels of hepatic proteins, such as albumin, transthyretin, and transferrin, can serve as markers of a nutritional index to screen for malnutrition and monitor the metabolic response to dietary intervention.

Blood hepatic proteins are synthesized mainly in liver Cited by: glucose-regulated protein 78 (GRP78), and protein disulfide isomerase were evaluated to clarify the presence of ER stress. Changing the diet from. Weight Gain Induced by High-Fat Feeding Involves Increased Liver Oxidative Stress.

Obesity. ; – doi: /oby Mercer1 JG, Archer ZA. Diet-induced obesity in the Sprague-Dawley rat: dietary manipulations and their effect on hypothalamic neuropeptide energy balance systems. Biochem Soc by: This implies not only that the liver faces absorbed nutrients, xenobiotics, toxins and gut-derived microorganisms, which need to be processed before entering the systemic circulation, first, but also suggests a hepatic role in the excretion of compounds into the intestinal lumen, in addition to the sensing and processing of gut-derived signals Cited by: 6.

Liver-associated lymphocytes • Normal human liver has 1x lymphoid cells • Predominantly in portal regions but also scattered • Predominant classes – NKT cells – gamma-delta T cells (most g/d T cells of any organ) – CD8+ T cells • Immune function of liver comparable to. Strong carcinogenic stress response induction of GST-P in hepatocytes Presently, strange phenomena were observed in the induction of GST-P + cells in rat liver as follows.

AAF is a complete carcinogen that has both initiator and promoter activities, but this agent is regarded to be noncarcinogenic at concentrations less than % [ 9, 10 ].Author: Kimihiko Satoh.

Proteomic Analysis of Liver Proteins in a Rat Model of Chronic Restraint Stress-Induced Depression terms of response to stimulus, cellular process, and cel-lular component organization or biogenesis were downex-pressed (Figure3(b)). In the cellular component category,Cited by: 8. The critical factor in selecting rat strains for oncogenicity studies appears to be familiarity with their, sometimes strain-specific, spontaneous pathology, married to an understanding of how external influences such as stress, housing, and diet can influence their outcomes.

Differential expression of liver proteins between obesity-prone and obesity-resistant rats in response to a high fat diet Article in The British journal.

The unfolded protein response: three branches, many outcomes. Secreted proteins begin their journey to the cell surface during translation into the ER. There, proteins are glycosylated, folded, and packaged into vesicles for transport to the Golgi apparatus to become further modified and then targeted to their final by: Liver HFE protein is decreased in rats fed an iron-deficient diet for 4 wk.

HFE, MT2, TFR2, and HJV protein content was determined in the plasma membrane-enriched fraction of young female rats fed an iron-deficient diet for 4 wk. Protein loading was 30 μg/well; arrows denote the specific bands, arrowhead denotes the cleaved HJV : Jana Frýdlová, Daniel W.

Rogalsky, Jaroslav Truksa, Lisa Traeger, Andrea U. Steinbicker, Martin Voku. Our previous study has demonstrated that long-term stress, known as chronic stress (CS), can aggravate nonalcoholic fatty liver disease in high-fat diet (HFD)-fed rat.

In this study, we tried to figure out which lipid metabolic pathways were impacted by CS in the HFD-fed rat. Male Sprague–Dawley rats (6 weeks of age, n = 8 per group) were fed with either standard diet Cited by: 6.

Dietary proteins elicit a wide range of nutritional and biological functions. Beyond their nutritional role as the source of amino acids for protein synthesis, they are instrumental in the regulation of food intake, glucose and lipid metabolism, blood pressure, bone metabolism and immune by:   Obesity has become a leading global health problem owing to its strong association with a high incidence of diseases.

To induce rat obesity using high fat diet (HFD) and to estimate oxidative stress markers in their liver, heart and kidney tissues in order to shed the light on the effect of obesity on these organs.

Sixty white albino rats weighing g were Cited by:   Dietary elements have long been known to play a critical role in the physiological or pathological response to tissue inflammation and oxidative stress (OS).

Accordingly, deficiency or excessive production of most dietary nutrients can impair the balance between the anti- and pro-oxidant agents, also causing liver by: stress proteins reaction against Al. Stress proteins are a superfamily of proteins, called heat-shock proteins (HSP) and glucose-regulated proteins (GRP), highly conserved from procariotes to mammals.

Major members are commonly expressed in the kidney and liver under physiological conditions but play a cytoprotective role during adverse conditions. Heat stress (HS) and related illnesses are a major concern in military, sports, and fire brigadiers.

HS results in physiologic responses of increased temperature, heart rate and sweating. In heat stroke, inflammatory response plays an important role and it is evidenced that turpentine (T) induced circulating inflammatory cytokines reduced survival rate and duration at Cited by: n-6/n-3 ratio in males.

Fish-based diet increased n-3, decreased n-6 and n-6/n-3 ratio vs. standard and milk-based diet in females. However, the ratio of individual FA in liver PL was also dietary-influenced, but with gender specific manner. While in females fish-based diet decreased AA (arachidonic acid) increased level of EPA (eicosapentaenoicCited by: 3.

RESEARCH ARTICLE Open Access Epithelial response to a high-protein diet in rat colon Martin Beaumont1, Mireille Andriamihaja1, Lucie Armand1, Marta Grauso1, Florence Jaffrézic2, Denis Laloë2, Marco Moroldo3, Anne-Marie Davila1, Daniel Tomé1, François Blachier1 and Annaïg Lan1* Abstract Background: High-protein diets (HPD) alter the large intestine.

Dibutyryl cyclic AMP addition resulted in an increase in 2-aminoisobutyrate transport at low substrate concentration, the response being greater after adaptation to a high-protein diet. Evidence is presented suggesting that the increased uptake of amino acids by the liver of rats fed on high-protein diets is obtained by developing favourable Cited by: Nonalcoholic fatty liver disease (NAFLD) is a serious health problem in developed countries.

We documented the effects of feeding with a NAFLD-inducing, methionine- and choline-deficient (MCD) diet, for 1–4 weeks on rat liver oxidative stress, with respect to a control diet. Glycogen, neutral lipids, ROS, peroxidated proteins, and SOD2 were investigated using histochemical Cited by:   Excess iron modulates endoplasmic reticulum stress-associated pathways in a mouse model of alcohol and high-fat diet-induced liver injury Terrence C H Tan 1, 2, 3 Darrell H G Crawford 1, 2.

The objective of this study was to determine the effects of creatine supplementation on liver biomarkers of oxidative stress in exercise-trained rats. Forty day-old adult male Wistar rats were assigned to four groups for the eight-week experiment. Control group (C) rats received a balanced control diet; creatine control group (CCr) rats received a balanced diet Cited by:   Evidence is presented suggesting that the increased uptake of amino acids by the liver of rats fed on high-protein diets is obtained by developing favourable gradients and enhancing transport capacities.

These adaptations allow sufficient amounts of amino acids to enter the liver, where accelerated metabolism plays a decisive role. PMCID: PMCCited by: Extra-virgin olive oil can protect the liver from oxidative stress. Researchers writing in BioMed Central’s open access journal Nutrition and Metabolism exposed rats to a moderately toxic herbicide known to deplete antioxidants and cause oxidative stress, finding that those rats fed on a diet containing the olive oil were partially protected from the resulting liver damage.

in the kidney and liver protein may have been in part or wholly TABLE II Effect of Thyroxine, Thyroidectomy, and Dinitrophenol on Proportion of Total Body Protein Found in Heart, Kidneys, and Liver of Rat on Adequate Diet - Protein per rat Proportion of WI total protein 5 ;j.

Abstract. Background: The chronic activation of the mechanistic (mammalian) target of rapamycin in complex 1 (mTORC1) in response to excess nutrients contributes to obesity-associated pathologies. Objective: To understand the initial events that ultimately lead to obesity-associated pathologies, the present study assessed mTORC1 responses in the liver Cited by: Rat Glucocorticoid Receptor and Heat Shock Protein 70 under Stress samples were mixed with denaturing buffer according to Laemmli () and kept at –70 °C before the analysis.

Separation of proteins by SDS-polyacrylamide gel electrophoresis and quantification by immunoblotting Aliquots of liver cytosols were boiled ( °C.

The effect of protein undernutrition on the activity of the smoothendoplasmic reticulum (microsomal) Ca2+-ATPase (SERCA) wasinvestigated.

After 12 weeks of ad libitum ingestion of low proteindiet (5% protein), a significant depression (pof liver ERCa2+-ATPase activity (% depression) was observed. However,no significant effects on Cited by: 5.

The notion that hepatic oxidative stress or the consequent lipid peroxidation may play a pathogenic role in alcoholic liver disease (ALD) 2 originated when Di Luzio () reported that the acute ethanol-induced increase in hepatic triglycerides in rats was prevented by the administration of antioxidants.

The detection of lipid peroxidation in hepatic homogenates and Cited by:   Dietary intake influence changes in fatty acids (FA) profiles in liver which plays a central role in fatty acid metabolism, triacylglycerol synthesis and energy homeostasis.

We investigated the effects of 4-weeks treatment with milk- and fish-based diet, on plasma biochemical parameters and FA composition of liver phospholipids (PL) in rats of both by: 3. the endoplasmic reticulum (ER) is responsible for synthesis of polypeptides and posttranslational modification and folding of peptides to form functional proteins for cellular function or secretion.

ER stress occurs when there is an excess of misfolded proteins and has been linked with an increasing number and wide variety of inherited and sporadic human diseases including Cited by:   Olive oil protects liver from oxidative stress, rat study finds Date: Octo Source: BioMed Central Summary: Extra-virgin olive oil can protect the liver from oxidative stress.

Effect of dietary protein on protein synthesis in skeletal muscle and liver. Rate of protein synthesis was determined in vivo as described in materials and methods. Results are expressed as nmol of phenylalanine incorporated into protein per mg tissue protein per hour and are means ± SE for 10–13 by: tributing to liver steatosis or fibrosis under ER stress (e.g., major urinary proteins in the liver, fatty acid binding proteins, adipose differentiation-related protein, cysteine-rich with epidermal growth factor–like domains 2, nuclear protein 1, and growth differentiation fac-tor 15).Cited by:   The unfolded protein response (UPR) improves endoplasmic reticulum (ER) protein folding in order to alleviate stress.

Yet it is becoming increasingly clear that the UPR regulates processes well beyond those directly involved in protein folding, in some cases by mechanisms that fall outside the realm of canonical UPR by: 6.